Publications

2018

Klinke, A., Berghausen, E., Friedrichs, K., Molz, S., Lau, D., Remane, L., Berlin, M., Kaltwasser, C., Adam. M., Mehrkens, D., Mollenhauer, M., Manchanda, K., Ravekes, T., Heresi, G.A., Aytekin, M., Dweik, R.A., Hennigs, J.K., Kubala, L., Michaëlsson, E., Rosenkranz, S., Rudolph, T.K., Hazen, S.L., Klose, H., Schermuly, R.T., Rudolph, V., Baldus, S. Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase. JCI Insight, 2018, 3(11).

Winkels H*, Ehinger E*, Vassallo M, Buscher K, Dinh H, Kobijama K, Hamers AJA, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Bala PA, Ghosh AK, Michel NA, Hoppe N, Hilgendorf I, Zirlik A, Hedrick C, Ley K’, Wolf D’. Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry. Circulation Research 2018, 122(12):1675-1688. *authors contributed Equally

Manchanda, K., Kolarova, H., Kerkenpaß, C., Mollenhauer, M., Vitecek, J., Rudolph, V., Kubala, L., Baldus, S., Adam, M., Klinke, A. MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge. Arterioscler Thromb Vasc Bio, 2018, 38(8):1859-1867.

Zelic, M., Roderick, J.E., O’Donnell, J.A., Lehman, J., Lim, S.E., Janardhan, H.P., Trivedi, C.M., Pasparakis, M., Kelliher, M.A. RIP kinase 1-dependent endothelial necroptosis underlies systemic inflammatory response syndrome. J Clin Invest, 2018, 128(5):2064-2075.

Manchanda, K., Kolarova, H., Kerkenpaß, C., Mollenhauer, M., Vitecek, J., Rudolph, V., Kubala, L., Baldus, S., Adam, M., Klinke, A. MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge. Arterioscler Thromb Vasc Bio, 2018, 38(8):1859-1867.

Adam, M., Kooreman, N.G., Jagger, A., Wagenhaeuser, U., Mehrkens, D., Wang, Y., Kayama, Y., Toyama, K., Raaz, U., Schellinger, I.N., Maegdefessel, L., Spin, J.M., Hamming, J.F., Quax, P.H.A., Baldus, S., Wu, J.C., Tsao, P.S. Systemic upregulation of IL-10 using a non-immunogenic vector reduces growth and rate of dissecting abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2018, 38(8):1796-1805.

2017

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N. CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice. Eur Heart J. 2017, 38(48):3590-3599.

Mollenhauer M, Friedrichs K, Lange M, Gesenberg J, Remane L, Kerkenpaß C, Krause J, Schneider J, Ravekes T, Maass M, Halbach M, Peinkofer G, Saric T, Mehrkens D, Adam M, Deuschl FG, Lau D, Geertz B, Manchanda K, Eschenhagen T, Kubala L, Rudolph TK, Wu Y, Tang WW, Hazen SL, Baldus S, Klinke A, Rudolph V. Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling. Circ Res. 2017, 121(1):56-70.

A. Schiavinato, D.R. Keene, T. Imhof, R. Doliana, T. Sasaki, G. Sengle. Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts. Sci Rep. 2017, 7:5526.

E. Brauchle, H. Bauer, P. Fernes, A. Zuk, K. Schenke-Layland, G. Sengle. Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models. Acta Biomater. 2017, 52:41-48.

2016

Lin, J., S. Kumari, C. Kim, T. M. Van, L. Wachsmuth, A. Polykratis and M. Pasparakis. RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016, 540(7631):124-128.

I. Bultmann-Mellin, J. Essers, P.M. van Heijingen, H. von Melchner, G. Sengle, A. Sterner-Kock A. Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice. Dis. Model Mech. 2016, 9:1367-74.

A.P. Wohl, H. Troilo, R.F. Collins, C. Baldock, G. Sengle. Extracellular Regulation of Bone Morphogenetic protein activity by the microfibril component fibrillin-1. J. Biol. Chem. 2016, 291(24):12732-12746.

A. Schiavinato, D.R.Keene, A.P. Wohl, D. Corallo, A. Colombatti, R. Wagener, M. Paulsson, P. Bonaldo, G. Sengle. Targeting of EMILIN-1 and EMILIN-2 to fibrillin microfibrils facilitates their incorporation into the extracellular matrix. J. Invest. Dermatol. 2016, 136:1150-1160.

2015

Pasparakis, M. and P. Vandenabeele. Necroptosis and its role in inflammation. Nature. 2015, 517(7534):311-320.

Raaz U, Zöllner AM, Schellinger IN, Toh R, Nakagami F, Brandt M, Emrich FC, Kayama Y, Eken S, Adam M, Maegdefessel L, Hertel T, Deng A, Jagger A, Buerke M, Dalman RL, Spin JM, Kuhl E, Tsao PS. Segmental aortic stiffening contributes to experimental abdominal aortic aneurysm development. Circulation. 2015, 131(20):1783-1795.

Kondylis, V., A. Polykratis, H. Ehlken, L. Ochoa-Callejero, B. K. Straub, S. Krishna-Subramanian, T. M. Van, H. M. Curth, N. Heise, F. Weih, U. Klein, P. Schirmacher, M. Kelliher and M. Pasparakis. NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015, 28(5):582-598.

Gerhardt MJ, Marsh J, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, De Angelis MM, Saint-Geniez M, Jacobo SMP. ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol 2017; 9: 516-532. Vantler M, Jesus J, Leppanen O, Scherner M, Berghausen EM, Mustafov L, Chen X, Kramer T, Zierden M, Gerhardt M, Ten Freyhaus H, Blaschke F, Sterner-Kock A, Baldus S, Zhao JJ, Rosenkranz S. Class IA phosphatidylinositol 3-kinase isoform p110alpha mediates vascular remodeling. Arterioscler Thromb Vasc Biol 2015; 35: 1434-1444.

Ten Freyhaus H, Berghausen EM, Janssen W, Leuchs M, Zierden M, Murmann K, Klinke A, Vantler M, Caglayan E, Kramer T, Baldus S, Schermuly RT, Tallquist MD, Rosenkranz S. Genetic ablation of PDGF-dependent signaling pathways abolishes vascular remodeling and experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2015; 35: 1236-1245.

G. Sengle, V. Carlberg, S.F. Tufa, N.L. Charbonneau, S. Smaldone, E.J. Carlson, F. Ramirez, D.R. Keene, L.Y. Sakai. Abnormal activation of BMP signaling causes myopathy in Fbn2 null mice. PLoS Genet. 2015, 11(6):e1005340.

I. Bultmann-Mellin, A. Conradi, A.C. Maul, K. Dinger, F. Wempe, A.P. Wohl, T. Imhof, F.T. Wunderlich, A.C. Bunck, T. Nakamura, K. Koli , W. Bloch, A. Ghanem, A. Heinz, H. von Melchner, G. Sengle, A. Sterner-Kock. Modeling autosomal recessive cutis laxa type 1C (ARCL1C) in mice reveals distinct functions of Ltbp-4 isoforms. Dis. Model Mech. 2015, 8:403-415.

2014

Lau D, Szöcs K, Klinke A, Rudolph T, Rudolph V, Streichert T, Blankenberg S, Baldus S. Myeloperoxidase upregulates endothelin receptor type B expression. J Mol Cell Cardiol. 2014, 69:76-82.

Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2014, 5:5214.

Adam M, Gajdova S, Kolarova H, Kubala L, Lau D, Geisler A, Ravekes T, Rudolph V, Tsao PS, Blankenberg S, Baldus S, Klinke A. Red blood cells serve as intravascular carriers of myeloperoxidase. J Mol Cell Cardiol. 2014, 74:353-363.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Senft K, Wibom R, Kudin A, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Wolfram S. Kunz WS, Trifunovic A. Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. PLoS Genetics 2014; 10: e1004385.

H. Troilo, A.V. Zuk, R.B. Tunnicliffe, A.P. Wohl, R. Berry, R.F. Collins, T.A. Jowitt, G. Sengle, and C. Baldock. Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding. Proc. Natl. Acad. Sci. U. S. A. 2014, 111:13063-13068.