Kardiovaskuläre Epidemiologie des Alterns

Die von Univ.-Prof. Ute Mons geleitete Arbeitsgruppe Kardiovaskuläre Epidemiologie des Alterns wird durch die Marga und Walter Boll-Stiftung gefördert und nutzt epidemiologische Methoden, um Forschungsfragen der Alternsforschung mit Schwerpunkt auf kardiovaskulären Erkrankungen zu bearbeiten.

Aufgabe der Arbeitsgruppe ist es, eine Kohortenstudie zu etablieren sowie klinische Daten aus der Routineversorgung am Herzzentrum für die Forschung zu erschließen. Auf Basis dieser Datenquellen soll ein epidemiologisches Forschungspaket bearbeitet werden, um die Entstehungsmechanismen, altersspezifischen Erscheinungsformen und den Stellenwert kardiovaskulärer Erkrankungen für den Gesamtgesundheitszustand und die Funktionalität in der älteren Bevölkerung vor dem Hintergrund der demographischen Alterung zu untersuchen. Ziel ist es insbesondere, Risikofaktoren und -marker zu identifizieren, um die Pathophysiologie, das Auftreten und die Prognose kardiovaskulärer Erkrankungen sowie ihrer Begleit- und Folgeerkrankungen besser zu verstehen und um gezielt präventive Maßnahmen zu entwickeln. Dabei sollen insbesondere auch Aspekte der Präventionsforschung sowie der Versorgungsforschung berücksichtigt werden.

Ausgewählte Publikationen

2020

  • Perna L, Zhang Y, Matías-García P, Ladwig KH, Wiechmann T, Wild B, Waldenberger M, Schöttker B, Mons U, Ihle A, Kliegel M, Schwettmann L, Peters A, Brenner H (2020) Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: Results from two longitudinal cohort studies. Transl Psychiatry. 10(1):323
  • Peter RS, Meyer ML, Mons U, Schöttker B, Keller F, Schmucker R, Koenig  W, Brenner H, Rothenbacher D (2020) Long-term trajectories of anxiety and depression in patients with stable coronary heart disease and risk of subsequent cardiovascular events. Depress Anxiety. 37(8):784-792

2019

  • Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, […], Mons U, […], Asselbergs FW (2019) Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events. Circ Genom Precis Med. 12(4):e002471
  • Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, […], Mons U, […], Asselbergs FW (2019) Subsequent Event Risk in Individuals With Established Coronary Heart Disease. Circ Genom Precis Med. 12(4):e002470
  • Meyer ML, Lin FC, Jaensch A, Mons U, Hahmann H, Koenig W, Brenner H, Rothenbacher D. Multi-state models of transitions in depression and anxiety symptom severity and cardiovascular events in patients with coronary heart disease (2019) PLoS One. 14(3):e0213334

2018

  • Gielen M, Hageman GJ, Antoniou EE, Nordfjall K, Mangino M, Balasubramanyam M, […], Mons U, […], Zeegers MP; TELOMAAS group (2018) Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies. Am J Clin Nutr. 108(3):453-475
  • Nabers A, Perna L, Lange J, Mons U, Schartner J, Güldenhaupt J, Saum KU, Janelidze S, Holleczek B, Rujescu D, Hansson O, Gerwert K, Brenner H (2018) Amyloid blood biomarker detects Alzheimer's disease. EMBO Mol Med. 10(5):e8763
  • Gao X, Zhang Y, Mons U, Brenner H (2018) Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults. Epigenetics. 13(8):846-857

2017

  • Breitling LP, Mons U, Hahmann H, Koenig W, Rothenbacher D, Brenner H (2017) Composite End Points: Implications of Changing Compositions With Longer Follow-Up. Circ Cardiovasc Qual Outcomes. 10(9):e003458
  • Mons U*, Müezzinler A*, Schöttker B, Dieffenbach AK, Butterbach K, Schick M, Peasey A, De Vivo I, Trichopoulou A, Boffetta P, Brenner H (2017) Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies. Am J Epidemiol. 185(12):1317-1326 (*equal contribution)
  • Zewinger S, Kleber ME, Tragante V, McCubrey RO, Schmidt AF, Direk K, […], Mons U, […], Speer T (2017) Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. Lancet Diabetes Endocrinol. 5(7):534-543
  • Pfetsch V, Sanin V, Jaensch A, Dallmeier D, Mons U, Brenner H, Koenig W, Rothenbacher D (2017) Increased Plasma Concentrations of Soluble ST2 Independently Predict Mortality but not Cardiovascular Events in Stable Coronary Heart Disease Patients: 13-Year Follow-up of the KAROLA Study. Cardiovasc Drugs Ther. 31(2):167-177
  • Breitling LP, Mons U, Hahmann H, Koenig W, Rothenbacher D, Brenner H (2017) The Longer, the Better? An Empirical Study of the Extent and Mechanisms of Attenuating Biomarker Associations in Cardiovascular Patient Cohorts. Clin Chem. 63(3):673-682
  • Mons U, Brenner H (2017) Demographic ageing and the evolution of smoking-attributable mortality: the example of Germany. Tob Control. 26(4):455-457

2016

  • Gao X, Mons U, Zhang Y, Breitling LP, Brenner H (2016) DNA methylation changes in response to active smoking exposure are associated with leukocyte telomere length among older adults. Eur J Epidemiol. 31(12):1231-1241
  • Jansen H, Koenig W, Jaensch A, Mons U, Breitling LP, Scharnagl H, Stojakovic T, Schunkert H, Brenner H, Rothenbacher D (2016) Prognostic Utility of Galectin-3 for Recurrent Cardiovascular Events During Long-term Follow-up in Patients with Stable Coronary Heart Disease: Results of the KAROLA Study. Clin Chem. 62(10):1372-9
  • Perna L, Zhang Y, Mons U, Holleczek B, Saum KU, Brenner H (2016) Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenetics. 8:64
  • Dallmeier D, Brenner H, Mons U, Rottbauer W, Koenig W, Rothenbacher D (2016) Growth Differentiation Factor 15, Its 12-Month Relative Change, and Risk of Cardiovascular Events and Total Mortality in Patients with Stable Coronary Heart Disease: 10-Year Follow-up of the KAROLA Study. Clin Chem. 62(7):982-92
  • Perna L, Mons U, Schöttker B, Brenner H (2016) Association of cognitive function and serum uric acid: Are cardiovascular diseases a mediator among women? Exp Gerontol. 81:37-41
  • Ihle A, Mons U, Perna L, Oris M, Fagot D, Gabriel R, Kliegel M (2016) The Relation of Obesity to Performance in Verbal Abilities, Processing Speed, and Cognitive Flexibility in Old Age: The Role of Cognitive Reserve. Dement Geriatr Cogn Disord. 42(1-2):117-26
  • Müezzinler A, Mons U, Dieffenbach AK, Butterbach K, Saum KU, Schick M, Stammer H, Boukamp P, Holleczek B, Stegmaier C, Brenner H (2016) Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort. Exp Gerontol. 74:1-8.
  • Meyer ML, Jaensch A, Mons U, Breitling LP, Hahmann H, Koenig W, Brenner H, Rothenbacher D (2016) Atrial fibrillation and long-term prognosis of patients with stable coronary heart disease: Relevance of routine electrocardiogram. Int J Cardiol. 203:1014-5
  • Perna L, Mons U, Rujescu D, Kliegel M, Brenner H (2016) Apolipoprotein E e4 and Cognitive Function: A Modifiable Association Results from Two Independent Cohort Studies. Dement Geriatr Cogn Disord. 41(1-2):35-45

2015

  • Imhof A, Koenig W, Jaensch A, Mons U, Brenner H, Rothenbacher D (2015) Long-term prognostic value of IgM antibodies against phosphorylcholine for adverse cardiovascular events in patients with stable coronary heart disease. Atherosclerosis. 243(2):414-20
  • Rothenbacher D, Dallmeier D, Mons U, Rosamond W, Koenig W, Brenner H (2015) Sexual Activity Patterns Before Myocardial Infarction and Risk of Subsequent Cardiovascular Adverse Events. J Am Coll Cardiol. 66(13):1516-7
  • Müezzinler A*, Mons U*, Dieffenbach AK, Butterbach K, Saum KU, Schick M, Stammer H, Boukamp P, Holleczek B, Stegmaier C, Brenner H (2015) Smoking habits and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort. Exp Gerontol. 70:18-25 (*equal contribution)
  • Zhang Y, Schöttker B, Florath I, Stock C, Butterbach K, Holleczek B, Mons U, Brenner H (2015) Smoking-Associated DNA Methylation Biomarkers and Their Predictive Value for All-Cause and Cardiovascular Mortality. Environ Health Perspect. 124(1):67-74
  • Mons U, Müezzinler A, Gellert C, Schöttker B, Abnet CC, Bobak M, de Groot L, Freedman ND, Jansen E, Kee F, Kromhout D, Kuulasmaa K, Laatikainen T, O'Doherty MG, Bueno-de-Mesquita B, Orfanos P, Peters A, van der Schouw YT, Wilsgaard T, Wolk A, Trichopoulou A, Boffetta P, Brenner H; CHANCES Consortium (2015) Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium. BMJ. 350:h1551
  • Perna L, Wahl HW, Mons U, Saum KU, Holleczek B, Brenner H (2015) Cognitive impairment, all-cause and cause-specific mortality among non-demented older adults. Age Ageing. 44(3):445-51
  • Rothenbacher D, Jaensch A, Mons U, Hahmann H, Becker T, Koenig W, Brenner H (2015) Prognostic value of one-year course of symptoms of anxiety and depression in patients with coronary heart disease: Role of physical activity and unmet medical need. Eur J Prev Cardiol. 22(9):1129-38

2014

  • Mons U, Hahmann H, Brenner H (2014) A reverse J-shaped association of leisure time physical activity with prognosis in patients with stable coronary heart disease: evidence from a large cohort with repeated measurements. Heart. 100(13):1043-9
  • Perna L, Mons U, Kliegel M, Brenner H (2014) Serum 25-hydroxyvitamin D and cognitive decline: a longitudinal study among non-demented older adults. Dement Geriatr Cogn Disord. 38(3-4):254-63

2013

  • Silbernagel G, Schöttker B, Appelbaum S, Scharnagl H, Kleber ME, Grammer TB, Ritsch A, Mons U, Holleczek B, Goliasch G, Niessner A, Boehm BO, Schnabel RB, Brenner H, Blankenberg S, Landmesser U, März W (2013) High-density lipoprotein cholesterol, coronary artery disease, and cardiovascular mortality. Eur Heart J. 34(46):3563-71
  • Mons U, Schöttker B, Müller H, Kliegel M, Brenner H (2013) History of lifetime smoking, smoking cessation and cognitive function in the elderly population. Eur J Epidemiol. 28(10):823-31