Arbeitsgruppe Herzinsuffizienz
Forschungsschwerpunkt
Die Herzinsuffizienz stellt die Endstrecke verschiedener kardiovaskulärer Erkrankungen dar und nimmt epidemische Ausmaße an, was zu einer enormen medizinischen und gesundheitsökonomischen Belastung führt. Ziel unserer Forschung ist es
- Die Pathophysiologie der Entwicklung und Progression der Herzinsuffizienz besser zu verstehen und damit die Möglichkeit für neue und gezielte Interventionen zu schaffen.
- Die klinische Behandlung und Versorgung herzinsuffizienter Patienten weiter zu verbessern. Hierzu werden funktionelle Auswirkungen altersrelevanter Bereiche der Herzinsuffizienztherapie, insbesondere der interventionellen Klappentherapie, evaluiert, und die Breitenversorgung herzinsuffizienter Patienten in strukturierten Versorgungsmodellen untersucht.
Prof. C.A. Schneider
Herznetz Köln
Priv.-Doz. Dr. med. Christian Templin
Klinik für Kardiologie, Universitätsspital Zürich
Internationales Takotsubo Register
Dr. J. Walker
InGef - Institut für angewandte Gesundheitsforschung Berlin GmbH
P. Ihle
PMV Forschungsgruppe
Duncker D, Westenfeld R, Konrad T, Pfeffer T, Correia de Freitas CA, Pfister R, Thomas D, Fürnkranz A, Andrié RP, Napp A, Schmitt J, Karolyi L, Wakili R, Hilfiker-Kleiner D, Bauersachs J, Veltmann C. Risk for life-threatening arrhythmia in newly diagnosed peripartum cardiomyopathy with low ejection fraction: a German multi-centre analysis. Clin Res Cardiol. 2017 Aug;106(8):582-589.
Puppe J, van Ooyen D, Neise J, Thangarajah F, Eichler C, Krämer S, Pfister R, Mallmann P, Wirtz M, Michels G. Evaluation of QTc Interval Prolongation in Breast Cancer Patients after Treatment with Epirubicin, Cyclophosphamide, and Docetaxel and the Influence of Interobserver Variation. Breast Care (Basel). 2017 Mar;12(1):40-44.
Tita C, Gilbert EM, Van Bakel AB, Grzybowski J, Haas GJ, Jarrah M, Dunlap SH, Gottlieb SS, Klapholz M, Patel PC, Pfister R, Seidler T, Shah KB, Zieliński T, Venuti RP, Cowart D, Foo SY, Vishnevsky A, Mitrovic V. A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction. Eur J Heart Fail. 2017 Oct;19(10):1321-1332
Iliadis C, Lee S, Kuhr K, Metze C, Matzik AS, Michels G, Rudolph V, Baldus S, Pfister R. Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review. Clin Res Cardiol. 2017 Dec;106(12):1005-1017
Metze C, Matzik AS, Scherner M, Körber MI, Michels G, Baldus S, Rudolph V, Pfister R. Impact of Frailty on Outcomes in Patients Undergoing Percutaneous Mitral Valve Repair. JACC Cardiovasc Interv. 2017 Oct 9;10(19):1920-1929.
Hilfiker-Kleiner D, Haghikia A, Berliner D, Vogel-Claussen J, Schwab J, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kindermann I, Kühl U, Angermann CE, Schlitt A, Fischer D, Podewski E, Böhm M, Sliwa K, Bauersachs J. Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study. Eur Heart J. 2017 Sep 14;38(35):2671-2679.
Pfister R, Ihle P, Mews B, Kohnen E, Wähner M, Karbach U, Aslan H, Höpp HW, Schneider CA. Feasibility of including patients with migration background in a structured heart failure management programme: A prospective case-control study exemplarily on Turkish migrants. PLoS One. 2017 Nov 8;12(11):e0187358
Di Benedetto L, Michels G, Luben R, Khaw KT, Pfister R. Individual and combined impact of lifestyle factors on atrial fibrillation in apparently healthy men and women: The EPIC-Norfolk prospective population study. Eur J Prev Cardiol. 2018 Jan 1:2047487318782379. doi:
Ghadri JR, ..., Michels G, Pfister R, ..., Templin C. Long-Term Prognosis of Patients With Takotsubo Syndrome. J Am Coll Cardiol. 2018 Aug 21;72(8):874-882.
Haghikia A, Schwab J, Vogel-Claussen J, Berliner D, Pfeffer T, König T, Zwadlo C, Moulig VA, Franke A, Schwarzkopf M, Ehlermann P, Pfister R, Michels G, Westenfeld R, Stangl V, Kühl U, Podewski E, Kindermann I, Böhm M, Sliwa K, Hilfiker-Kleiner D, Bauersachs J. Bromocriptine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction. Clin Res Cardiol. 2019 Mar;108(3):290-297.
Di Vece D,... Michels G, Pfister R, ... Templin C. Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome. Circulation. 2019 Jan 15;139(3):413-415.
Weiss M, Michels G, Eberhardt F, Fehske W, Winter S, Baer F, Choi YH, Albus C, Steven D, Baldus S, Pfister R. Anxiety, depression and quality of life in acute high risk cardiac disease patients eligible for wearable cardioverter defibrillator: Results from the prospective multicenter CRED-registry. PLoS One. 2019 Mar 11;14(3):e0213261
Hohmann C, Hohnloser SH, Jacob J, Walker J, Baldus S, Pfister R. Non-Vitamin K Oral Anticoagulants in Comparison to Phenprocoumon in Geriatric and Non-Geriatric Patients with Non-Valvular Atrial Fibrillation. Thromb Haemost. 2019 Mar 21. doi: 10.1055/s-0039-1683422
Gili S,... Michels G, Pfister R, ...Templin C. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry. Eur Heart J. 2019 May 16. pii: ehz170. doi: 10.1093/eurheartj/ehz170. [Epub ahead of print]
Vitinius F, Reklat A, Hellmich M, Klask E, Wahlers T, Rahmanian PB, Pfister R, Müller-Ehmsen J, Albus C. Prediction of survival on the waiting list for heart transplantation and of posttransplant nonadherence - results of a prospective longitudinal study. Clin Transplant. 2019 May 28:e13616. doi: 10.1111/ctr.13616. [Epub ahead of print]
Cammann VL,... Michels G, Pfister R, ... Templin C. Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry. J Am Heart Assoc. 2019 Aug 6;8(15):e010881. doi: 10.1161/JAHA.118.010881
Wischnewsky MB, ...Michels G, Pfister R, ... Templin C. Prediction of short- and long-term mortality in takotsubo syndrome: the InterTAK Prognostic Score. Eur J Heart Fail. 2019 Aug 27. doi: 10.1002/ejhf.1561. [Epub ahead of print]
