Joseph C, Berghausen EM, Behringer A, Rauch B, Ten Freyhaus H, Gnatzy-Feik LL, Krause M, Wong DWL, Boor P, Baldus S, Vantler M, Rosenkranz S (2022) Coagulation-independent effects of thrombin and factor Xa: role of protease-activated receptors in pulmonary hypertension. Cardiovasc Res Feb 1:cvac004. doi: 10.1093/cvr/cvac004. Online ahead of print.

Butt L, Unnersjo-Jess D, Hohne M, Hahnfeldt R, Reilly D, Rinschen MM, Plagmann I, Diefenhardt P, Brahler S, Brinkkotter PT, Brismar H, Blom H, Schermer B, Benzing T (2022) Super-resolution imaging of the filtration barrier suggests a role for Podocin R229Q in genetic predisposition to glomerular disease. J Am Soc Nephrol 33: 138-154.

Joseph C, Berghausen EM, Behringer A, Rauch B, Ten Freyhaus H, Gnatzy-Feik LL, Krause M, Wong DWL, Boor P, Baldus S, Vantler M, Rosenkranz S (2022) Coagulation-independent effects of thrombin and factor Xa: role of protease-activated receptors in pulmonary hypertension. Cardiovasc Res Feb 1:cvac004. doi: 10.1093/cvr/cvac004. Online ahead of print.

Croon M, Szczepanowska K, PopovicM, LienkampC, SenftK, BrandscheidCP, Theresa BockT, Gnatzy-FeikL, AshurovA,ActonRA, KaulH, PujolC, Rosenkranz S, KrügerM, Trifunovic A (2022)FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Science Adv Apr 8;8(14):eabn7105.

Rosenkranz S, Feldman J, McLaughlin VV, Rischard F, Lange T, White JR, Peacock AJ, Gerhardt F, Ebrahimi R, Brooks G, Satler C, Frantz RP, for the ARROW Study Group (2022) A prospective, randomized, double-blind, placebo-controlled study of selonsertib in pulmonary arterial hypertension (ARROW). Lancet Respir Med 2022; 10: 35-46.

Soltanmohammadi N, Wang S, Schumacher B (2022) Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun 13(1):701.

Rumyantseva A, Popovic M, Trifunovic A (2022) CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain Feb 11;e109169.

Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K (2022) Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science 375(6577): 214-221.

Nettersheim FS, Braumann S, Kobiyama K, Orecchioni M, Vassallo M, Miller J, Ali A, Roy P, Saigusa R, Wolf D, Ley K, Winkels H (2022) Autoimmune regulator (AIRE) deficiency does not affect atherosclerosis and CD4 T cell immune tolerance to Apolipoprotein B. Front Cardiovasc Med 8: 812769. doi: 10.3389/fcvm.2021.812769.

Berghausen EM, Janssen W, Vantler M, Gnatzy-Feik LL, Krause M, Behringer A, Joseph C, Zierden M, Freyhaus HT, Klinke A, Baldus S, Alcazar MA, Savai R, Pullamsetti SS, Wong DW, Boor P, Zhao JJ, Schermuly RT, Rosenkranz S (2021) Disrupted PI3K subunit p110α signaling protects against pulmonary hypertension and reverses established disease in rodents. J Clin Invest 131(19):e136939.

Mollenhauer M, Bokredenghel S, Geißen S, Klinke A, Morstadt T, Torun M, Strauch S, Schumacher W, Maass M, Konradi J, Peters VBM, Berghausen E, Vantler M, Rosenkranz S, Mehrkens D, Braumann S, Nettersheim F, Hof A, Simsekyilmaz S, Winkels H, Rudolph V, Baldus S, Adam M, ten Freyhaus H (2021) Stamp2 protects from maladaptive structural remodeling and systolic dysfunction in post-ischemic hearts by attenuating neutrophil activation. Front Immunol  Aug 31; doi: 10.3389/fimmu.2021. 701721.

Braumann S, Schumacher W, Im NG, Nettersheim FS, Mehrkens D, Bokredenghel S, Hof A, Nies RJ, Adler C, Winkels H, Knöll R, Freeman BA, Rudolph V, Klinke A, Adam M, Baldus S, Mollenhauer M*, Geißen S* (2021) Nitro-oleic acid (NO2-OA) improves systolic function in dilated cardiomyopathy by attenuating myocardial fibrosis. Int J Mol Sci Aug 22; 22(16):9052.

Nettersheim FS, Lemties J, Braumann S, Geißen S, Bokredenghel S, Nies R, Hof A, Winkels H, Freeman BA, Klinke A, Rudolph V, Baldus S, Mehrkens D, Mollenhauer M, Adam M (2021) Nitro-oleic acid (NO2-OA) reduces thoracic aortic aneurysm progression in a mouse model of Marfan syndrome. Cardiovasc Res Jul 29; cvab256. doi: 10.1093/cvr/cvab256. Online ahead of print.

Butt L, Unnersjo-Jess D, Hohne M, Schermer B, Edwards A, Benzing T (2021) A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int 100: 1054-1062.

Benzing T, Salant D (2021) Insights into glomerular filtration and albuminuria. N Engl J Med 384: 1437-1446.

Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC (2021) Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci 24: 913-929.

Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TA, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC (2021) Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab 3: 1662-1679.

Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen CA (2021) Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun 12: 5249. 10.1038/s41467-021-25380-2.

BrosseronF, MaassA, Kleineidam L, RavichandranKA, González PG, McManus RM, Ising C, Santarelli F, Kolbe C, Häsler LM, Wolfsgruber S, Marquié M, Boada M, Orellana A,  de Rojas I, Röske S, Peters O, Cosma N, Cetindag A, Wang X, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Schott BH, Bürger K, Janowitz D, Dichgans M, Perneczky R, Rauchmann B, Teipel S, Kilimann I, Göerß D, Laske C, Munk MH, Düzel E, Yakupov R, Dobisch L, Metzger CD, Glanz W, Ewers M, Dechent P, Haynes JD, Scheffler K, Roy N, Rostamzadeh A, Teunissen CE, Marchant NL, Spottke A, Jucker M, Latz E, Wagner M, Mengel D, Synofzik M, Jessen F, Ramirez A, Ruiz A, Heneka MT and the DELCODE study group (2021) Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer´s disease. Neuron S0896-6273(21)01033-3.

Kummer MP*, Ising C*, Kummer C, Sarlus H, Griep A, Vieira-Saecker A, Schwartz S, Halle A, Brückner M, Händler K, Schultze JL, Beyer M, Latz E, Heneka MT (2021) Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology. EMBO J 40:e108662. *equal contribution

Shi Y, Sairam Andey S, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Schlaffner C, Wesseling H, Yamada K, Qin W, Manis M, Remolina Serrano J, Benitez BA, Steen J, Schmidt RE, Artyomov M, Ulrich JD, Holtzman DM (2021) Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron 109:2413-2426.e7.

Berghausen EM, Janssen W, Vantler M, Gnatzy-Feik LL, Krause M, Behringer A, Joseph C, Zierden M, Freyhaus HT, Klinke A, Baldus S, Alcazar MA, Savai R, Pullamsetti SS, Wong DW, Boor P, Zhao JJ, Schermuly RT, Rosenkranz S (2021) Disrupted PI3K subunit p110α signaling protects against pulmonary hypertension and reverses established disease in rodents. J Clin Invest 131(19): e136939.

Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ (2021) The central role of DNA damage in the ageing process. Nature 592(7856): 695-703.

Meyer DH, Schumacher B (2021) BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy. Aging Cell 20(3):e13320.

Willenborg S, Sanin DA, Jais A, DingX, UlasT, NüchelJ, PopovicM, MacVicarT, LangerT, SchultzeJL, Roers A, PearceEJ, BrüningJC, TrifunovicA, EmingSA (2021) Different metabolic functions of mitochondria orchestrate phase-specific repair behaviors in macrophages. Cell Metab Dec 7;33(12):2398-2414.e9.

Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, and Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Science Adv May 26;7(22):eabf0971

Bebber CM, Thomas ES, Chen Z, Stroh J, Androulidaki A, Schmitt A, Höhne MN, Stüker L, de Pádua Alves C, Khonsari A, Dammert MA, Parmaksiz F, Tumbrink HL, Beleggia F, Sos ML, Riemer J, George J, Brodesser S, Thomas RK, Reinhardt HC, von Karstedt S (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun 12(1):2048. doi: 10.1038/s41467-021-22336-4.

Winkels H, Ghosheh Y, Kobiyama K, Kiosses WB, Orecchioni M, Ehinger E, Surywanshi V, Herrera S, Marchovecchio P, Riffelmacher T, Thiault N, Kronenberg M, Wolf D, Seumois G, Vijayanand P, Ley K (2021) Thymus-derived CD4+CD8+ cells reside in mediastinal adipose tissue and the aortic arch. J Immunol 207(11):2720-2732.

Mollenhauer M, Mehrkens D, Klinke A, Lange M, Remane L, Friedrichs K, Braumann S, Geißen S, Simsekyilmaz S, Nettersheim FS, Lee S, Peinkofer G, Geisler AC, Geis B, Schwoerer AP, Carrier L, Freeman BA, Dewenter M, Luo X, El-Armouche A, Wagner M, Adam M, Baldus S, Rudolph V (2020) Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis. Sci Rep Sep 18;10(1):15319.

Butt L, Unnersjö-Jess D, Höhne M, Edwards A, Binz-Lotter J, Reilly D, Hahnfeldt R, Ziegler V, …, Brismar H, Blom H, Schermer B, Benzing T (2020) A molecular mechanism explaining albuminuria in kidney disease. Nature Metab 2: 461-474.

Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minere M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC (2020) PNOC(ARC) neurons promote hyperphagia and obesity upon high-fat-diet feeding. Neuron 106: 1009-1025.

Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC (2020). MCH neurons regulate permeability of the median eminence barrier. Neuron 107: 306-319.

Lippert RN, Hess S, Klemm P, Burgeno LM, Jahans-Price T, Walton ME, Kloppenburg P, Brüning JC (2020) Maternal high-fat diet during lactation reprograms the dopaminergic circuitry in mice. J Clin Invest 130: 3761-3776.

Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC (2020) NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nat Commun 11: 442. 10.1038/s41467-020-14291-3.

Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC (2020) GLP-1 receptor signaling in astrocytes regulates fatty acid oxidation, mitochondrial integrity, and function. Cell Metab 31: 1189-1205.

Turpin-Nolan SM, Brüning JC (2020) The role of ceramides in metabolic disorders: when size and localization matters. Nature Rev Endocrinol 16: 224-233.

Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature580: 391-395.

Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020) FADD and Caspase-8 regulate gut homeostasis and inflammation by controlling MLKL- and GSDMD-mediated death of intestinal epithelial cells. Immunity52: 978-993.

Laurien L, Nagata M, Schunke H, Delanghe T, Wiederstein JL, Kumari S, Schwarzer R, Corona T, Kruger M, Bertrand MJM, Kondylis V, Pasparakis M (2020) Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat Commun11: 1747.

Rosenkranz S, Howard LS, Gomberg-Maitland M, Hoeper MM (2020) Systemic consequences of pulmonary hypertension and right heart failure. Circulation 141: 678-692.

Batool M*, Berghausen EM*, Zierden M, Vantler M, Schermuly RT, Baldus S, Rosenkranz S, ten Freyhaus H (2020) The six-transmembrane protein Stamp2 protects from pulmonary vascular remodeling and pulmonary hypertension in mice. Basic Res Cardiol 115(6): 68. doi: 10.1007/s00395-020-00826-8. *contributed equally.

Wang S, Meyer DH, Schumacher B (2020) H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol 27(12):1165-1177.

Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B (2020) A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res 48(19): 10973-10985.

Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerro-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020) A salvage pathway maintains functional respiratory complex I. Nat Commun Apr 2;11(1): 1643. doi: 10.1038/s41467-020-15467-7.

Pedrera L, Espiritu RA, Ros U, Weber J, Schmitt A, Stroh J, Hailfinger S, Karstedt von S, García-Sáez AJ (2020) Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death and Differentiation149: 1-14.

Clemente LP, Rabenau M, Tang S, Stanka J, Cors E, Stroh J, Culmsee C, Karstedt von S (2020) Dynasore blocks ferroptosis through combined modulation of iron uptake and inhibition of mitochondrial respiration. Cells 9: 2259.

Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC (2019) CerS6-derived sphingolipids interact with Mff and promote mitochondrial fragmentation in obesity. Cell 177: 1536-1552.

Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönnecke HS, Krüger M, Nissbrand H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC (2019) The fat mass and obesity-associated protein (FTO) regulates locomotor responses to novelty via D2R medium spiny neurons. Cell Rep 27: 3182-3198.

Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC (2019) CerS1-derived C(18:0) ceramide in skeletal muscle promotes obesity-induced insulin resistance. Cell Rep 26: 1-10.

Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, VieiraSaecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT (2019) NLRP3 inflammasome activation drives tau pathology. Nature 575:669-673.

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M (2019) A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol21: 731-742.

Eftychi C, Schwarzer R, Vlantis K, Wachsmuth L, Basic M, Wagle P, Neurath MF, Becker C, Bleich A, Pasparakis M (2019) Temporally distinct functions of the cytokines IL-12 and IL-23 drive chronic colon inflammation in response to intestinal barrier impairment. Immunity51: 367-380.

Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B (2019) Somatic niche cells regulate the CEP-1/p53-mediated DNA damage response in primordial germ cells. Dev Cell 50(2): 167-183.

Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, Negri GL, von Karstedt S, Lockwood WW, Schaffer P, Leprivier G, Sorensen PH (2019) Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. PNAS 116(19):9433-9442.

McArdle S, Buscher K, Ghoseh Y, Pramod AB, Miller J, Winkels H, Wolf D, Ley K (2019)  Migratory and dancing macrophage subsets in atherosclerotic lesions. Circ Res 125: 1038-1051.

Bianchini M, Duchene J, Santovito D, Schloss M, Evrard M, Winkels H, Aslani M, Mohanta SK, Horckmans M, Blanchet X, Lacy M, von Hundelshausen P, Atzler D, Habenicht A, Gerdes N, Pelisek J, Guan Ng L, Steffens S, Weber C, Megens RTA (2019) CD274/PD-L1 marks non-classical monocytes to unveil new features of their origin and immunoregulatory function. Sci Immunol 21;4(36)

Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Sluetter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E (2019) Deficiency of the T cell regulator CBL-B aggravates atherosclerosis by inducing CD8⁺ T cell-mediated macrophage death. Eur Heart J40: 372-382.

Manchanda K, Kolarova H, Kerkenpaß C, Mollenhauer M, Vitecek J, Rudolph V, Kubala L, Baldus S, Adam M, Klinke A (2018) MPO (Myeloperoxidase) reduces endothelial glycocalyx thickness dependent on its cationic charge. Arterioscler Thromb Vasc Biol 38: 1859-1867.

Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S (2018) Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase. JCI Insight 3: e97530.

Rinschen MM, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P, ..., Benzing T*, Huber TB* (2018) A multilayered quantitative in vivo expression atlas of the podocyte unravels kidney disease candidate genes. Cell Rep 23: 2495-3508.   *corresponding author

Brandt C, Nolte H, Henschke S, Engström Ruud L, Awazawa M, Morgan DA, Gabel P, Sprenger HG, Hess ME, Günther S, Langer T, Rahmouni K, Fenselau H, Krüger M, Brüning JC (2018) Food perception primes hepatic ER homeostasis via melanocortin-dependent control of mTOR activation. Cell 175: 1321-1335.

Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC (2018) Mild impairment of mitochondrial OXPHOS promotes fatty acid utilization in POMC neurons and improves glucose homeostasis in obesity. Cell Rep 25: 383-397.

Ising C, Heneka MT (2018) Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration. Cell Death Dis 9:120.

Klinke A, Berghausen E, Friedrichs K, Molz S, Lau D, Remane L, Berlin M, Kaltwasser C, Adam M, Mehrkens D, Mollenhauer M, Manchanda K, Ravekes T, Heresi GA, Aytekin M, Dweik RA, Hennigs JK, Kubala L, Michaëlsson E, Rosenkranz S, Rudolph TK, Hazen SL, Klose H, Schermuly RT, Rudolph V, Baldus S (2018) Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase. JCI Insight 3: e97530.

Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P,  Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 2018 Mar 27. pii: e45126. doi: 10.15252/embr.201745126.

Kimura T*, Kobiyama K*, Winkels H*, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orrechioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K (2018) Regulatory CD4⁺ T cells Recognize Major Histocompatibility Complex Class II Molecule-restricted Peptide Epitopes of Apolipoprotein B. Circulation 138: 1130-1143. *contributed equally.

Winkels H*, Ehinger E*, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K’, Wolf D’ (2018) Atlas of the Immune Cell Repertoire in mouse atherosclerosis defined by single-cell RNA sequencing and mass cytometry.Circ Res 122: 1675-1688. *contributed equally.

Mollenhauer M, Friedrichs K, Lange M, Gesenberg J, Remane L, Kerkenpaß C, Krause J, Schneider J, Ravekes T, Maass M, Halbach M, Peinkofer G, Saric T, Mehrkens D, Adam M, Deuschl FG, Lau D, Geertz B, Manchanda K, Eschenhagen T, Kubala L, Rudolph TK, Wu Y, Tang WW, Hazen SL, Baldus S, Klinke A, Rudolph V (2017) Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling. Circ Res 121: 56-70.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Ghandirajan RK, Krüger M, Brinkkötter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B (2017) YAP-mediated mechanotransduction determines the podocyte's response to damage. Science Signal 10: 53.

Awazawa M, Gabel P, Tsaousidou E, Nolte H, Krüger M, Schmitz J, Ackermann PJ, Brandt C, Altmüller J, Motameny S, Wunderlich FT, Kornfeld JW, Blüher M, Brüning JC (2017) A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat Med 23: 1466-1473.

Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz- Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC (2017) IL-6/Stat3- Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. Cell Metab 26: 171-184.

Gerhardt MJ, Marsh J, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, De Angelis MM, Saint-Geniez M, Jacobo SMP (2017). ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol 2017 Aug 10: 1-16.

Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Krüger M, Schumacher B (2017) Multilayered reprogramming in response to persistent DNA damage in C. elegans. Cell Rep 20: 2026-2043.

Wilson DM3rd*, Rieckher M*, Williams AB, Schumacher B. (2017) Systematic analysis of DNA crosslink repair pathways during development and aging in C. elegans. Nucleic Acids Res 45: 9467-9480. (*equal contribution)

Aradjanski M, Dogan SA, Lotter S, Wang S, Hermans S, Wibom R, Rugarli EI, Trifunovic A (2017) DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells. Hum Mol Genet 26:4181-4189.

Rudolph TK, Ravekes T, Klinke A, Friedrichs K, Mollenhauer M, Pekarova M, Ambrozova G, Martiskova H, Kaur JJ, Matthes B, Schwoerer A, Woodcock SR, Kubala L, Freeman BA, Baldus S, Rudolph V (2016) Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodeling and atrial fibrillation. Cardiovasc Res 109: 174-84.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC (2016) AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell 165:125-138.

Brant L, Georgomanolis T, Nikolic M, Brackley CA, Kolovos P, van Ijcken W, Grosveld FG, Marenduzzo D, Papantonis A (2016) Exploiting native forces to capture chromosome conformation in mammalian cell nuclei. Mol Syst Biol 12: 891.

Kolovos P, Georgomanolis T, Nikolic M, Koeferle A, Larkin JD, Feuerborn A, Zirkel A, Brant L, Gusmao EG, Costa IG, van Ijcken W, Cook PR, Grosveld F, Papantonis A (2016) Binding of nuclear factor kappa‐B to non‐canonical consensus sites reveals its multimodal role during the early inflammatory response. Genome Res 26: 1478-1489.

Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A, Pasparakis M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540: 124-128.

Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M (2016) The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun 7: 12508.

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M (2016) NEMO prevents RIP kinase 1- mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and - independent functions. Immunity 44: 553-567.

Rosenkranz S, Gibbs JSR, Wachter R, De Marco T, Vonk-Noordegraaf A, Vachiéry JL (2016) Left ventricular heart failure and pulmonary hypertension. Eur Heart J 37: 942-954.

Opitz CF, Hoeper MM, Gibbs JSR, Kaemmerer H, Pepke-Zaba J, Coghlan JG, Scelsi L, D’Alto M, Olsson KM, Ulrich S, Scholtz W, Schulz U, Grünig E, Vizza CD, Staehler G, Bruch L, Huscher D, Pittrow D, Rosenkranz S (2016) Pre-capillary, combined, and post-capillary pulmonary hypertension: A pathophysiological continuum. J Am Coll Cardiol 68: 368-378.

Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner B, Schumacher B#, Hoppe T# (2016) E4 Ubiquitin Ligase Specific Ubiquitylation Hubs Coordinate DNA Double Strand Break Repair and Apoptosis. Nat Struct Mol Biol 23: 995-1002 #co-corresponding authors

Babu V, Schumacher B (2016) C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair (Amst) 41: 8-15.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M (2016) Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet 25: 5365-5382.

Szczepanowska K, Maiti P, Kukat A, Hofetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35: 2566-2583.

Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Kukat A, Trifunovic A (2016) Loss of ClpP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-964.

Ising C, Koeler S, Braehler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat C, Müller RU, Wiesner R, Langer T, Benzing T, Brinkkötter, PT (2015) Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. Embo Mol Med 7: 275-287.

Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC (2015) Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP-neurons. Cell 162: 1404-17.

Caudron-Herger M, Cook PR, Rippe K, Papantonis A. (2015) Dissecting the nascent human transcriptome by analysing the RNA content of transcription factories. Nucleic Acids Res 43: e95.

Kelly S, Georgomanolis T, Zirkel A, Diermeier S, O'Reilly D, Murphy S, Längst G, Cook PR, Papantonis A. (2015) Splicing of many human genes involves sites embedded within introns. Nucleic Acids Res 43: 4721-4732.

Kelly S, Greenman C, Cook PR, Papantonis A. (2015) Exon skipping is correlated with exon circularization. J Mol Biol pii: S0022-2836(15)00112-6.

Vantler M, Jesus J, Leppänen O, Scherner M, Berghausen EM, Mustafov L, Chen X, Kramer T, Zierden M, Gerhardt F, ten Freyhaus H, Blaschke F, Sterner-Kock A, Baldus S, Zhao JJ, Rosenkranz S (2015) Class IA phosphatidylinositol 3-kinase isoform p110mediates vascular remodeling. Arterioscler Thromb Vasc Biol 35: 1434-1444.

Ten Freyhaus H, Berghausen EM, Janssen W, Leuchs M, Zierden M, Murmann K, Klinke A, Vantler M, Caglayan E, Kramer T, Baldus S, Schermuly RT, Tallquist MD, Rosenkranz S (2015) Genetic ablation of PDGF-dependent signaling pathways abolishes vascular remodeling and experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 35: 1236-1245.

Adam M, Gajdova S, Kolarova H, Kubala L, Lau D, Geisler A, Ravekes T, Rudolph V, Tsao PS, Blankenberg S, Baldus S, Klinke A (2014) Red blood cells serve as intravascular carriers of myeloperoxidase. J Mol Cell Cardiol 74: 353-363.

Klinke A, Möller A, Pekarova M, Ravekes T, Friedrichs K, Berlin M, Scheu KM, Kubala L, Kolarova H, Ambrozova G, Schermuly RT, Woodcock SR, Freeman BA, Rosenkranz S, Baldus S, Rudolph V, Rudolph TK (2014) Protective effects of 10-Nitro-Oleic acid in a hypoxia-induced murine model of pulmonary hypertension. Am J Respir Cell Mol Biol 51: 155-162.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T (2014) Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol 25: 1509-1522.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodessor S, Hammerschmidt P, Wunderlich C, Mauer J, Xu E, Brönneke H, Trifunicnovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014) Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20: 678-86.

Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönnecke H, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC (2014) Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 15: 423–430.

Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC (2014) Neonatal Insulin Action Impairs Hypothalamic Neurocircuit formation in response to maternal high-fat feeding. Cell 156: 495-509.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrié RP, Stöckigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS One 9: e89307.

Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Längst G, Papantonis A. (2014) TNFα signaling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning. Genome Biol 15: 536.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M (2014) RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513: 90-94.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Senft K, Wibom R, Kudin A, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Wolfram S. Kunz WS, Trifunovic A (2014) Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. PLoS Genetics 10: e1004385.

Lubos E, Schlüter M, Vettorazzi E, Goldmann B, Lubs D, Schirmer J, Treede H, Reichenspurner H, Blankenberg S, Baldus S, Rudolph V (2014) MitraClip therapy in surgical high-risk patients: Identification of echocardiographic variables impacting acute procedural outcome. JACC Cardiovasc Interv 7: 394-402.

Mueller M, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014) DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol 16: 1168–1179.

Babu V, Hofmann K, Schumacher B (2014) A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair 24: 57-62.

Behrens A, van Deursen J, Rudolph KL, Schumacher B (2014) Impact of genomic damage and ageing on stem cell function. Nat Cell Biol 16: 201-207.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A (2014) Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity. PLoS Genet 10: e1004385.

Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A (2014) Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab 19: 458-469.

Hackl M, Burford JL, Villanueva K, Lam L, Susztak K, Schermer B, Benzing T, Peti-Peterdi J (2013) Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nature Med 19: 1661-1666.

Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC (2013) The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci 16:1042-1048.

Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC. (2013) Obesityinduced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 494: 111-115.

Brackley CA, Taylor S, Papantonis A, Cook PR, Marenduzzo D (2013). Nonspecific bridginginduced attraction drives clustering of DNA-binding proteins and genome organization. Proc Natl Acad Sci U S A 110: E3605-E3611.

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B (2013) DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501(7467):416-420.