Publications

2017

Mollenhauer M, Friedrichs K, Lange M, Gesenberg J, Remane L, Kerkenpaß C, Krause J, Schneider J, Ravekes T, Maass M, Halbach M, Peinkofer G, Saric T, Mehrkens D, Adam M, Deuschl FG, Lau D, Geertz B, Manchanda K, Eschenhagen T, Kubala L, Rudolph TK, Wu Y, Tang WW, Hazen SL, Baldus S, Klinke A, Rudolph V (2017) Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling. Circ Res 121: 56-70.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Ghandirajan RK, Krüger M, Brinkkötter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B (2017) YAP-mediated mechanotransduction determines the podocyte's response to damage. Science Signal 10: 53.

Awazawa M, Gabel P, Tsaousidou E, Nolte H, Krüger M, Schmitz J, Ackermann PJ, Brandt C, Altmüller J, Motameny S, Wunderlich FT, Kornfeld JW, Blüher M, Brüning JC (2017) A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle. Nat Med 23: 1466-1473.

Theurich S, Tsaousidou E, Hanssen R, Lempradl AM, Mauer J, Timper K, Schilbach K, Folz- Donahue K, Heilinger C, Sexl V, Pospisilik JA, Wunderlich FT, Brüning JC (2017) IL-6/Stat3- Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. Cell Metab 26: 171-184.

Gerhardt MJ, Marsh J, Morrison M, Kazlauskas A, Khadka A, Rosenkranz S, De Angelis MM, Saint-Geniez M, Jacobo SMP (2017). ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity. J Mol Cell Biol 2017 Aug 10: 1-16.

Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Krüger M, Schumacher B (2017) Multilayered reprogramming in response to persistent DNA damage in C. elegans. Cell Rep 20: 2026-2043.

Wilson DM3rd*, Rieckher M*, Williams AB, Schumacher B. (2017) Systematic analysis of DNA crosslink repair pathways during development and aging in C. elegans. Nucleic Acids Res 45: 9467-9480. (*equal contribution)

Aradjanski M, Dogan SA, Lotter S, Wang S, Hermans S, Wibom R, Rugarli EI, Trifunovic A (2017) DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells. Hum Mol Genet 26:4181-4189.

2016

Rudolph TK, Ravekes T, Klinke A, Friedrichs K, Mollenhauer M, Pekarova M, Ambrozova G, Martiskova H, Kaur JJ, Matthes B, Schwoerer A, Woodcock SR, Kubala L, Freeman BA, Baldus S, Rudolph V (2016) Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodeling and atrial fibrillation. Cardiovasc Res 109: 174-84.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC (2016) AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue. Cell 165:125-138.

Brant L, Georgomanolis T, Nikolic M, Brackley CA, Kolovos P, van Ijcken W, Grosveld FG, Marenduzzo D, Papantonis A (2016) Exploiting native forces to capture chromosome conformation in mammalian cell nuclei. Mol Syst Biol 12: 891.

Kolovos P, Georgomanolis T, Nikolic M, Koeferle A, Larkin JD, Feuerborn A, Zirkel A, Brant L, Gusmao EG, Costa IG, van Ijcken W, Cook PR, Grosveld F, Papantonis A (2016) Binding of nuclear factor kappa‐B to non‐canonical consensus sites reveals its multimodal role during the early inflammatory response. Genome Res 26: 1478-1489.

Lin J, Kumari S, Kim C, Van T-M, Wachsmuth L, Polykratis A, Pasparakis M (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature, 540: 124-128.

Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M (2016) The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun 7: 12508.

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M (2016) NEMO prevents RIP kinase 1- mediated epithelial cell death and chronic intestinal inflammation by NF-κB-dependent and - independent functions. Immunity 44: 553-567.

Rosenkranz S, Gibbs JSR, Wachter R, De Marco T, Vonk-Noordegraaf A, Vachiéry JL (2016) Left ventricular heart failure and pulmonary hypertension. Eur Heart J 37: 942-954.

Opitz CF, Hoeper MM, Gibbs JSR, Kaemmerer H, Pepke-Zaba J, Coghlan JG, Scelsi L, D’Alto M, Olsson KM, Ulrich S, Scholtz W, Schulz U, Grünig E, Vizza CD, Staehler G, Bruch L, Huscher D, Pittrow D, Rosenkranz S (2016) Pre-capillary, combined, and post-capillary pulmonary hypertension: A pathophysiological continuum. J Am Coll Cardiol 68: 368-378.

Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner B, Schumacher B#, Hoppe T# (2016) E4 Ubiquitin Ligase Specific Ubiquitylation Hubs Coordinate DNA Double Strand Break Repair and Apoptosis. Nat Struct Mol Biol 23: 995-1002 #co-corresponding authors

Babu V, Schumacher B (2016) C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA. DNA Repair (Amst) 41: 8-15.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M (2016) Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease. Hum Mol Genet 25: 5365-5382.

Szczepanowska K, Maiti P, Kukat A, Hofetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35: 2566-2583.

Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, Kukat A, Trifunovic A (2016) Loss of ClpP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-964.

2015

Ising C, Koeler S, Braehler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat C, Müller RU, Wiesner R, Langer T, Benzing T, Brinkkötter, PT (2015) Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. Embo Mol Med 7: 275-287.

Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC (2015) Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP-neurons. Cell 162: 1404-17.

Caudron-Herger M, Cook PR, Rippe K, Papantonis A. (2015) Dissecting the nascent human transcriptome by analysing the RNA content of transcription factories. Nucleic Acids Res 43: e95.

Kelly S, Georgomanolis T, Zirkel A, Diermeier S, O'Reilly D, Murphy S, Längst G, Cook PR, Papantonis A. (2015) Splicing of many human genes involves sites embedded within introns. Nucleic Acids Res 43: 4721-4732.

Kelly S, Greenman C, Cook PR, Papantonis A. (2015) Exon skipping is correlated with exon circularization. J Mol Biol pii: S0022-2836(15)00112-6.

Vantler M, Jesus J, Leppänen O, Scherner M, Berghausen EM, Mustafov L, Chen X, Kramer T, Zierden M, Gerhardt F, ten Freyhaus H, Blaschke F, Sterner-Kock A, Baldus S, Zhao JJ, Rosenkranz S (2015) Class IA phosphatidylinositol 3-kinase isoform p110mediates vascular remodeling. Arterioscler Thromb Vasc Biol 35: 1434-1444.

Ten Freyhaus H, Berghausen EM, Janssen W, Leuchs M, Zierden M, Murmann K, Klinke A, Vantler M, Caglayan E, Kramer T, Baldus S, Schermuly RT, Tallquist MD, Rosenkranz S (2015) Genetic ablation of PDGF-dependent signaling pathways abolishes vascular remodeling and experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 35: 1236-1245.

2014

Adam M, Gajdova S, Kolarova H, Kubala L, Lau D, Geisler A, Ravekes T, Rudolph V, Tsao PS, Blankenberg S, Baldus S, Klinke A (2014) Red blood cells serve as intravascular carriers of myeloperoxidase. J Mol Cell Cardiol 74: 353-363.

Klinke A, Möller A, Pekarova M, Ravekes T, Friedrichs K, Berlin M, Scheu KM, Kubala L, Kolarova H, Ambrozova G, Schermuly RT, Woodcock SR, Freeman BA, Rosenkranz S, Baldus S, Rudolph V, Rudolph TK (2014) Protective effects of 10-Nitro-Oleic acid in a hypoxia-induced murine model of pulmonary hypertension. Am J Respir Cell Mol Biol 51: 155-162.

Rinschen MM, Wu X, König T, Pisitkun T, Hagmann H, Pahmeyer C, Lamkemeyer T, Kohli P, Schnell N, Schermer B, Dryer S, Brooks BR, Beltrao P, Krueger M, Brinkkoetter PT, Benzing T (2014) Phosphoproteomic analysis reveals regulatory mechanisms at the kidney filtration barrier. J Am Soc Nephrol 25: 1509-1522.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodessor S, Hammerschmidt P, Wunderlich C, Mauer J, Xu E, Brönneke H, Trifunicnovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC (2014) Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 20: 678-86.

Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönnecke H, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC (2014) Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol 15: 423–430.

Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC (2014) Neonatal Insulin Action Impairs Hypothalamic Neurocircuit formation in response to maternal high-fat feeding. Cell 156: 495-509.

Friedrichs K, Adam M, Remane L, Mollenhauer M, Rudolph V, Rudolph TK, Andrié RP, Stöckigt F, Schrickel JW, Ravekes T, Deuschl F, Nickenig G, Willems S, Baldus S, Klinke A (2014) Induction of atrial fibrillation by neutrophils critically depends on CD11b/CD18 integrins. PLoS One 9: e89307.

Diermeier S, Kolovos P, Heizinger L, Schwartz U, Georgomanolis T, Zirkel A, Wedemann G, Grosveld F, Knoch TA, Merkl R, Cook PR, Längst G, Papantonis A. (2014) TNFα signaling primes chromatin for NF-κB binding and induces rapid and widespread nucleosome repositioning. Genome Biol 15: 536.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M (2014) RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513: 90-94.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Senft K, Wibom R, Kudin A, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Wolfram S. Kunz WS, Trifunovic A (2014) Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. PLoS Genetics 10: e1004385.

Lubos E, Schlüter M, Vettorazzi E, Goldmann B, Lubs D, Schirmer J, Treede H, Reichenspurner H, Blankenberg S, Baldus S, Rudolph V (2014) MitraClip therapy in surgical high-risk patients: Identification of echocardiographic variables impacting acute procedural outcome. JACC Cardiovasc Interv 7: 394-402.

Mueller M, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B (2014) DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol 16: 1168–1179.

Babu V, Hofmann K, Schumacher B (2014) A C. elegans homolog of the Cockayne syndrome complementation group A gene. DNA Repair 24: 57-62.

Behrens A, van Deursen J, Rudolph KL, Schumacher B (2014) Impact of genomic damage and ageing on stem cell function. Nat Cell Biol 16: 201-207.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A (2014) Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity. PLoS Genet 10: e1004385.

Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A (2014) Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell Metab 19: 458-469.

2013

Hackl M, Burford JL, Villanueva K, Lam L, Susztak K, Schermer B, Benzing T, Peti-Peterdi J (2013) Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. Nature Med 19: 1661-1666.

Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC (2013) The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci 16:1042-1048.

Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC. (2013) Obesityinduced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 494: 111-115.

Brackley CA, Taylor S, Papantonis A, Cook PR, Marenduzzo D (2013). Nonspecific bridginginduced attraction drives clustering of DNA-binding proteins and genome organization. Proc Natl Acad Sci U S A 110: E3605-E3611.

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B (2013) DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501(7467):416-420.

Publications from 2001 - 2012

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